The last 2022 edition of the GEWEX Quarterly features a retrospective of the International Satellite Cloud Climatology Project (ISCCP), an introduction to the Explaining and Predicting Earth System Change Lighthouse Activity (EPESC LHA), project progress from the GEWEX Hydroclimatology Panel (GHP), developments from the GEWEX Data and Analysis Panel (GDAP) coupled with science updates from a global energy and water cycle workshop, news from the Global Land-Atmosphere System Studies (GLASS) Panel on new and ongoing projects, and refinements to the ANDEX plan for improving understanding and prediction of Andes hydrology.